Corneal Cross-Linking

Unique and flexible solutions for corneal cross-linking

Servimed industrial distributes an innovate cxl product line, characterized by maximun flexibility, in terms of both applications and protocols

KERATOCONUS

Keratoconus is a non-inflammatory disease, characterized by a progressive thinning and deformation of the cornea, which becomes curved and asymmetrical in the center (ectasia), assuming a cone shape.

The causes of the disease are still unclear, but it has been demonstrated that keratoconus involves collagen fibers degradation, which leads to the loss of intramolecular bonds. These phenomena of thinning and deformation have a faster evolution at a young age and may progress for the entire life. In advanced keratoconus stages, the apex of the corneal cone can become opaque and, rarely, perforate. Corneal deformation can cause irregular astigmatism, usually myopic, with progressive and invalidating visual loss, which can hardly be corrected by glasses or contact lenses.

CORNEAL CROSS-LINKING TREATMENT (CXL)

Corneal Cross-linking (CXL) is a para-surgical technique developed in Dresden in 1998. It consists of a photodynamical polymerization of the corneal stroma, aimed at increasing its strength by multiplying collagen fibers, thereby stabilizing the cornea and halting keratoconus’ progression. CXL is performed using a riboflavin (vitamin B2) based solution combined with an ultraviolet light source (UV-A).

Cross-linking increases and strengthens collagen fibers bonds, stiffening corneal tissues, and halting the ectasia progression. Many clinical and experimental studies demonstrated a significant increase in corneal stiffness after CXL. The technique can be performed with (CXL EPI-OFF) or without corneal epithelium removal (CXL EPI-ON).

Our corneal cross-linking product line:

CF X-LINKER. Corneal Cross-Linking System

The CF X-LINKER ® system has advanced technical features, along with a wide treatment choice for a complete and smooth surgical experience.

RIBOFLAVIN. Ribocross te & Ribofast

The only riboflavin solutions that use Vitamin E TPGS as a penetration enhancer. Safe and effective results in both EPI-OFF and EPI-ON. In addition, they are the only solutions that can be used with Custom Fast CXL protocol.

CF X-LINKER ®. The complete solution for corneal cross-linking

Advanced and unique technical features, with a wide selectable treatment range.

THE COMPLETE SOLUTION FOR CORNEAL CROSS-LINKING

Thanks to the field experience and the collaboration with leading ophthalmologists, the new CF X-LINKER ® generation was developed with improved technical features, along with a wider treatment range, for a complete and smooth surgical experience.

MAXIMUM FLEXIBILITY

WIDE RANGE OF APPLICATIONS

CF X-LINKER ® is one of the most complete solutions for corneal ectasias treatment, thanks to its wide treatment range. It is an open system, that can be used with every riboflavin solution on the market, without needing additional materials or expenses. CF X-LINKER ® gives you the option to select between different protocols: EPI-OFF or EPI-ON, with a continuous or pulsed UV emission, up to fully customizable user presets, to give every patient a specific treatment.

EASY TO USE

SMOOTH USER EXPERIENCE

The new CF X-LINKER ® interface has been optimized to provide an easy and smooth experience during every phase. Every operation is managed through the touchscreen 10’’ monitor, equipped with exclusive proprietary software. The integrated camera allows users to follow the whole treatment in real-time. CF X-LINKER ® allows users to compile, save, or print a treatment report at the end of each procedure. Users can easily save these reports in the internal database, export them via the integrated USB port or print them out.

CUSTOM FAST CXL

UNIQUE AND INNOVATIVE TREATMENT

CF X-LINKER ® is the only system that can perform Custom Fast CXL (cfCXL), customized, low power EPI-ON cross-linking treatment. Our proprietary software uses a mathematical model to calculate the procedure parameters automatically, based on patients’ topographic and pachymetric values. Custom Fast CXL allows the user to provide patients with a treatment tailored to their specific needs while maintaining high safety standards.

Custom Fast CXL is supported by several international publications, including a 7-year follow-up.

(Custom Fast CXL can be performed only with CF X-LINKER ® system and RIBOCROSS ® te/RIBOFAST riboflavin solutions).

RIBOCROSS te & RIBOFAST

PATENTED AND CE-MARKED SOLUTIONS, COMPATIBLE WITH EVERY CXL PROTOCOL AND UV DEVICE ON THE MARKET.

UNIQUE AND INNOVATIVE RIBOFLAVIN SOLUTIONS

THE ONLY SOLUTIONS TO USE VITAMIN E TPGS AS PENETRATION ENHANCER.

SERVImed Industrial’s riboflavin solutions have unique, innovative and patented formulations: thanks to Vitamin E TPGS, in synergy with riboflavin, it is possible to get safe and effective results in both EPI-OFF and EPI-ON. These results are certified by international publications, including a 7-year follow up.

CUSTOM FAST CXL

RIBOCROSS ® te and RIBOFAST are the only riboflavin solutions that can be used in Custom Fast CXL (cfCXL), exclusive customized low power EPI-ON treatment, in combination with CF X-LINKER ® system.

The proprietary software uses a mathematical model to calculate treatment parameters, based on patients’ topographic and pachymetric data: this leads to a customized treatment, tailored to every patient’s needs, which allows for a safe and effective procedure.

Custom Fast CXL is supported by clinical studies and publications on international papers, including a clinical 7-year follow up, unique among EPI-ON procedures. Custom Fast CXL can be performed only with CF X-LINKER ® system and RIBOCROSS ® te/RIBOFAST solutions.

RIBOCROSS TE

OPHTHALMIC SOLUTION FOR CORNEAL CROSS-LINKING

RIBOCROSS ® te is a patented ophthalmic solution, fit for every CXL protocol. Thanks to Vitamin E TPGS as an enhancer, it allows for an effective penetration in the whole corneal stroma, including in EPI-ON, for safe and effective results.

FEATURES:

  • Ophthalmic solution with 10% Dextran;
  • International patent;
  • Vitamin E TPGS: corneal penetration enhancer;
  • High effectiveness in both EPI-ON and EPI-OFF;
  • Can be used with every protocol and UV device on the market;
  • Can be used in CUSTOM FAST CXL (cfCXL)

RIBOFAST

DEXTRAN FREE OPHTHALMIC SOLUTION FOR CORNEAL CROSS-LINKING

RIBOFAST is a patented dextran free ophthalmic solution, fit for every CXL protocol. Thanks to Vitamin E TPGS as an enhancer, it allows for an effective penetration in the whole corneal stroma, including in EPI-ON, for safe and effective results.

FEATURES:

  • Dextran free ophthalmic solution;
  • International patent;
  • Vitamin E TPGS: corneal penetration enhancer;
  • High effectiveness in both EPI-ON and EPI-OFF;
  • Can be used with every protocol and UV device on the market;
  • Can be used in CUSTOM FAST CXL (cfCXL).

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