Rexon-Eye® – Reinvent Dry Eye Treatment

The only ophthalmology device based on QMR technology

Rexon-Eye®

Rexon-Eye is a non-invasive device that provides durable treatment for all forms of dry eye syndromes. It works by applying low-power high-frequency electric fields, capable of stimulating the metabolism and natural regeneration of cells.

The treatment addresses all types of the dry eye syndromes, both evaporative and hypo-secretive, as evidenced by several subjective and objective measurements.

Rexon-Eye® is the only device based on QMR® technology (Quantum Molecular Resonance) for the treatment of pathologies in the ophthalmology field that may be caused by cell malfunction of some organs.

This is the case with the lacrimal and Meibomian glands in dry eye disease.
By stimulating the metabolism and natural regeneration of these cells, Rexon-Eye can restore their correct physiological behavior.

How Rexon-Eye is made

The Rexon-Eye device consists of:

A specific generator, capable of producing alternating electric current with a specific patented frequency spectrum, between 4 MHz and 64 MHz, which constitutes the QMR signal.

A simple graphical user interface, that allows the specialist to quickly and easily set the treatment parameters and start the therapy.

A neutral plate, positioned on the seat in contact with the body that allows for a closed electrical circuit.

A suitably designed mask, to be worn over the lids with eyes closed, which contains the two application electrodes, one for each eye.

How Rexon-Eye works

The electric field generated by Rexon-Eye, applied to the ocular surface by means of the mask electrode, stimulates and accelerates the natural regeneration processes that take place in tissues.

The treatment protocol envisages:

  • 20-minute sessions, in which the eyes are stimulated individually, alternating every 30 seconds
  • 4 sessions, once a week, over a total period of 4 weeks

The power is initially set to a value of 4 and may then be adjusted separately for each eye.

Rexon-Eye therapy is non-invasive, does not cause any pain, does not require analgesic products or external cooling systems.

For effective therapy, follow the advice on the Treatment page.

Results and benefits

The Rexon-Eye device is used successfully in patients with dry eye, of a hyposecretive, evaporative or mixed type.

QMR treatment promotes the regeneration of the Lacrimal Functional Unit (LFU), thus improving the activity of the glandular tissues involved.

The induction of natural tears in a greater quantity and of better quality leads to a physiological rebalancing of the tear film, with significant clinical benefits and a considerable improvement in the patient’s state of well-being.

For further information go to the Clinical Studies page.

As with any other type of therapeutic agent, the patient’s response to Rexon-Eye therapy is characterized by individual variability:

some patients experience improvement in their condition soon after the first session, for example, with increased tear production

others must wait longer for the treatment to start the natural regeneration process.

In 2016, Rexon-Eye obtained the EC certification mark as a ‘Medical device for the treatment of ocular surface disorders’ and, in 2018, after further clinical studies, it entered the therapeutic devices market.

The device is present in the National List of Medical Devices of the Italian Ministry of Health as a Class IIa device in the CND ‘Instrumentation for therapeutic and surgical treatments in ophthalmology.’

Rexon-Eye is currently patented in Europe, China, US, Russia, South Africa, Australia, Korea, and is pending in other countries.

Resono Ophthalmic is the only company in the world that applies the revolutionary QMR ® technology to the treatment of ophthalmic diseases, which has proven to be able to provide significant benefits to patients with dry eye disease.

It is, therefore, appropriate to briefly introduce some basic aspects of this technology.

Electricity and the human body

It has been known for centuries that electric currents flow throughout our body and carry the signals necessary for its operation.

The heart and muscles in general contract because they are stimulated by an electric current, just as the eyes and ears allow us to see and hear because they generate and transmit electrical signals to our brain.

These electrical stimuli are generated by the body itself, but others may be artificially generated and applied by biomedical tools designed for this purpose.

Electric currents and regenerative processes

It was recently discovered that electrial signals are able to interact with the regulation of cell behavior and homeostasis of tissues (read the paper); phenomena that are the basis of many healing processes. (read the paper)

The main difficulty of artificial stimulation is to be able to generate the correct signals, that is, those able to interact with the organism to stimulate regenerative processes.

Discovery of the QMR effect

Research activities aimed at making a surgical cut without a temperature increase, conducted at the company, Telea Medical, led to the discovery of a physical effect called Quantum Molecular Resonance (QMR)*, in which an alternating electrical signal containing a specific frequency range, from 4 to 16 MHz, appears to be in resonance, that is, it has the same frequency as the oscillations of molecular bonds in biological tissues.

This particular situation allows for maximizing the transfer of energy from the electrical stimulus signal to the biological tissue, with a minimum dispersion in heat and, therefore, maximum efficiency in opening the molecular bonds (see on the right an image of the perfect cut obtained).

* QMR is a registered trademark of Telea Medical.

This discovery was originally used by the company to develop a revolutionary cold electro-scalpel (read the paper), which allows for obtaining a surgical cut effect without raising the temperature of tissues.

It is a highly innovative electro-scalpel, which allows for significant benefits for the patient and surgical procedures in very delicate areas of the body, such as the brain and nerve endings.

QMR for tissue regeneration

In subsequent experiments, it was discovered that an alternating electrical signal with an even wider frequency range (from 4 to 64 MHz) is able to obtain another significant effect, namely, precisely the stimulation of metabolism and natural regeneration of biological tissues and cells.

Various phenomena observed experimentally can explain this effect: the mechanical deformation of the cell membrane, the increase in calcium release, and the stimulation of metabolism (read the paper).

Using sophisticated analysis techniques (DNA micro-array), a recent study on cells treated with QMR has experimentally demonstrated its ability to stimulate the over-expression of some genes involved in the natural tissue regeneration processes (read the paper).

This new discovery paved the way for the application of QMR to various areas of medicine, such as aesthetic medicine, pain management medicine, and physiotherapy.

In this regard, it is interesting to point out the significant results obtained by QMR stimulation in healing deep wounds in the limbs, also for their potential application to healing corneal wounds (read the paper).

Rexon-Eye field of application

The Rexon-Eye device currently finds its main application in the treatment of dry eye (DE), a complex pathology due to trauma, inflammation, deficit, infection, or other, which causes abnormalities of the ocular surface and eyelids, and in the composition of the tear film, with significant repercussions on vision.

Rexon-Eye, unique in the therapeutic device landscape, is successfully used in all DE patients, whether they are hyposecretive (“aqueous deficient”, ADDE), evaporative (EDE), or mixed.

The Rexon-Eye Difference

Compared to other devices on the market that often simply warm the treated area and are only able to alleviate symptoms of the disease, Rexon-Eye applies a treatment capable of stimulating recovery of normal function of the organs involved.

The hypothesis behind these benefits is that the QMR signal applied by the device stimulates the natural regeneration of the lacrimal system of patients, reactivating glandular tissue and physiological tear secretion, and thus providing functional benefits to the entire lacrimal functional unit.

26 subjects, with evaporative or hyposecretive DE, were treated and then examined up to one year from the end of the treatment.

An important aspect of this study is the confirmation of the long-term benefits of Rexon-Eye treatment: some of the measured parameters were still improving at the end of the one-year observation period. The results of the study are reported in a work published in the British Journal of Ophthalmology, to which reference may be made for further information.

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25 subjects, all affected by Evaporative DE (Meibomian Gland Disease, MGD), were treated with Rexon-Eye.

In this specific type of DE, it is important to evaluate the benefit obtained on the functionality of the Meibomian glands, which are responsible for generating the lipid substance that limits tear evaporation. The parameters measured to characterize this specific functionality, relating to the quantity and quality of the secretion, showed a significant improvement after treatment with Rexon-Eye.

The results of the study are reported in a work published in Cornea, to which reference may be made for further information.

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9 subjects, affected by an advanced mixed form of DE (both evaporative and hyposecretive), were treated with Rexon-Eye.

In this particularly difficult to treat patient group, the measured parameters also showed significant improvement after treatment with Rexon-Eye.

The results of the study are reported in the ARVO 2020 congress proceedings, to which reference may be made for further information.

FIND OUT MORE

9 subjects, affected by an advanced mixed form of DE (both evaporative and hyposecretive), were treated with Rexon-Eye.

In this particularly difficult to treat patient group, the measured parameters also showed significant improvement after treatment with Rexon-Eye.

The results of the study are reported in the ARVO 2020 congress proceedings, to which reference may be made for further information.

FIND OUT MORE

Tips for optimal treatment with Rexon-Eye®

It is well known that dry eye is a multifactorial disease.

Alongside a pathological or genetic basis, the incidence of environmental and psychophysical factors on the severity of symptoms is well known.

That’s why with a regenerative therapy such as Rexon-Eye®, we believe it is necessary to create the best environmental conditions for the success of the treatment.

Although many patients report an immediate benefit just after the first session, the action of Rexon-Eye® requires a physiological time for reactivating the cells and the body as well needs to be prepared for the healing process, to obtain effective and long-lasting results.

Therefore we believe that a relaxed atmosphere in a reserved and calm place is a key factor in ensuring your patients the maximum results from the treatment.

In this page, we’ve gathered some tips and useful information to create the most suitable environment for the treatment.

Main aspects of the treatment

Rexon-Eye® is a non-invasive therapy that does not cause any pain or discomfort. It does not require analgesics or cooling systems on the skin (e.g., gel).

During the treatment, patients only experience a slight and pleasant sensation of warmth underneath the mask.

Resono Ophthalmic is not aware of any trauma or physical damage that may be caused by the Rexon-Eye® usage.

Patients excluded from the treatment:

  • pregnant women
  • patients with implanted active medical devices (e.g., pacemakers or hearing aids)
  • infants or children (under 18 years)
  • patients undertaking cancer therapy
  • patients who underwent ocular surgery in the last month

The recommended treatment consists of

4 session

20 minutes each

1 week break

To create a well-being environment

We suggest setting up in your clinic a special area reserved for the treatment, following these indications:

  • find a space suitable for the Rexon-Eye® treatment, quiet and possibly isolated from the other activities of the clinic
  • use for treatment a comfortable reclining chair, where the patient may feel relaxed
  • ensure warm lighting with a soft and wide shade

Before starting the treatment

  • Make sure to place the mask with uniform contact over the eyes, without exerting high pressure
  • Lower the brightness of the light sources

Treatment delivery strips

Rexon-Eye must be used with special disposable waterproof facial strips, worn between the mask electrode and the eyelid surface.

These strips help to uniformly spread the electrical current over the whole eye surface, increasing its capability to reach Meibomian and lacrimal glands on the patients. Moreover, the electrical properties of their fabric allow minimizing the current intensity capable to elicit the QMR® therapeutic effect.

They also play an essential role in assuring patient personal hygiene, by avoiding bacteria and virus transmission.

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Within this environment, the session can be even more pleasant and relaxing with some simple expedients

Download the treatment leaflet for the patient

Technical data

  • Technical data
  • LCD display
  • Supply Voltage and frequency: 100-230V ~ 50 / 60Hz
  • Maximum Power Consumption: 300VA
  • Maximum output power: 40W / 200 Ω dual channel (mask)
  • Weight: 8kg
  • Dimensions: 40x18x35 cm
  • Output Frequency: frequency spectrum between 4MHz and 64MHz (patented spectrum)
  • Rexon-Eye is classified Class IIa According to Annex 9 of Directive 93/42 /EEC and s.m.i. (2007/47/EC)

Rexon-Eye is covered by patent in Europe EP3349848A1, USA US 10,376,691 B2, Russia RU2723113, Korea KR 10-2183930 and Australia 2016344594. Patents pending in several other countries.

Who we are

How Rexon-Eye works

Rexon-Eye first tutorial by Resono

Luca Vigo, head of Dry Eye Center (CARONES Vision) about Rexon-Eye device

Interview with Alfredo Ruggeri, Chairman of Resono Ophthalmic company

REXON EYE Vietnam webinar 2021 07 23

Rexon-eye Brochure
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Treatment leaflet for the patient
Download PDF

Biophysical effects of high frequency electrical field (4-64 MHz) on muscle fibers in culture
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Favorable Tissue Effects of Quantum Molecular Resonance Device (Vesalius®) Compared with Standard Electrocautery
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Quantum molecular resonance technology in hard-to-heal extremity wounds: histological and clinical results.
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Transcutaneous periorbital electrical stimulation in the treatment of dry eye.
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Innovative radiofrequency electrotherapy significantly reduces cornea perforation in an alkali burn murine model
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High Frequency Electrotherapy for the Treatment of Meibomian Gland Dysfunction
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Mixed dry eye patients successfully treated by the innovative high-frequency electrotherapy device Rexon-Eye®
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Improvement in mixed-type dry eye patients after treatment with the QMR®-based electrotherapy device Rexon-Eye®
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